Harmonin
WebUSH1C/harmonin isoforms are expressed in a wide range of tissues, yet studies on expression and subcellular localization of harmonin in rodent retinae have not been definitive (10,15,(21) (22) (23 ...
Harmonin
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WebMar 1, 2003 · These results demonstrate that SANS underlies USH1G. The SANS protein contains three ankyrin domains and a sterile alpha motif, and its C-terminal tripeptide presents a class I PDZ-binding motif. We showed, by means of co-transfection experiments, that SANS associates with harmonin, a PDZ domain-containing protein responsible for … WebFeb 22, 2024 · IPEX patients typically harbor circulating autoantibodies against harmonin (HAA), a 75-kDa protein also known as USH1C, expressed in the intestinal epithelia and renal tubules (70, 71, 77, 84). Although the assay is not widely accessible, positivity of serum or plasma samples to HAA is highly suggestive of the diagnosis ( 85 ).
WebHarmonin is a protein that in humans is encoded by the USH1C gene. It is expressed in sensory cells of the inner ear and retina, where it plays a role in hearing, balance, and … WebMay 26, 2010 · In cells coexpressing the Cdh23 cytoplasmic binding protein harmonin, a large fraction of harmonin became colocalized with Cdh23 in microvilli. Using this assay and in vitro protein binding assays, we formulated an alternative model for Cdh23-harmonin binding, in which the primary interaction is between the harmonin N-domain and a 35 …
WebAll lanes : Anti-USH1C/Harmonin antibody [EPR8131] (ab133763) at 1/2500 dilution Lane 1 : Squirrel cochlea Lane 2 : Mouse cochlea Lane 3 : Squirrel colon Lane 4 : Mouse colon Lane 5 : Caco2 cells Secondary All … Web[Harmonin is a component of the auditory mechanotransduction apparatus]
WebOct 2, 2024 · Harmonin is a postsynaptic density-95/discs-large/ZO-1 (PDZ) domain-containing scaffold protein, which organizes the Usher protein network of the inner ear …
Webharmonin. ( har'mō-nin ), A protein encoded by the gene responsible for cases of Usher type 1C syndrome; may act as a rafting agent in gating complexes in stereocilia. Farlex … st giles hotel central london wc1b 3ghWebNov 13, 2007 · Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in … st giles hotel johor bookingWebOct 19, 2024 · Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides mechanistic insight into its role in DNA repair. Niranjan Kumar, … st giles hospice referralWebcd07347: harmonin_N_like. Download alignment. N-terminal protein-binding module of harmonin and similar domains, also known as HHD (harmonin homology domain) This domain is found in harmonin, and similar proteins such as delphilin, and whirlin. These are postsynaptic density-95/discs-large/ZO-1 (PDZ) domain-containing scaffold proteins. st giles hotel singaporeWebHarmonin is a submembranous protein containing PDZ domains that is encoded by the gene responsible for Usher syndrome type 1C (USH1C), a disease characterised by congenital pro-found deafness and vestibular dysfunction and delayed onset retinopathy leading to blindness. Harmonin consists of three classes of isoforms [9, 48]. Harmonin … st giles hotel jb check in timeWebAug 15, 2024 · August 15, 2024, 12:13 PM. Angie Harmon has found the perfect way to celebrate turning 46 years old: posting shamelessly stunning bikini photos. The actress celebrated her Aug. 10 birthday with a ... st giles hotel in londonWebMar 29, 2024 · Harmonin can adopt two different structural states, 'open' and 'closed', as a result of the self-interaction between its domains. In summary, our studies provide novel insight into the functional relationship between USH1 and USH2 proteins in the cochlea and the retina as well as the disease mechanisms underlying USH1 and USH2. st giles hotel london london wc1