WebThe Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has been reported to be altered in others. Despite the general agreement reached by the scientific community … WebDickkopf-1 (DKK1), a Wnt inhibitor, plays a vital role for over the past decades regarding its role in the regulation of several types of cancers. However, studies have shown that DKK1 is expressed differently in cancer and plays a role as a cancer-promoting factor or a tumor suppressor, which is worthy of further exploration.
Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis …
WebThrough an integrated approach to ovarian cancer biomarker discovery that combines proteomics with transcriptomics and bioinformatics, our laboratory has identified folate-receptor 1 (FOLR1) and Dickkopf-related protein 3 (Dkk-3) as putative biomarkers. ... The role of FOLR1 in the pathogenesis of ovarian cancer warrants further investigation ... WebNov 24, 2024 · WNT signaling pathway inhibitor Dickkopf-1 (DKK1) is related to cancer progression; however, its diagnostic and prognostic potential have not been investigated in a pan-cancer perspective. In this study, multiple bioinformatic analyses were conducted to evaluate therapeutic value of DKK1 in human cancers. The Cancer Genome Atlas … csharp tabs
[PDF] Wnt inhibitor Dickkopf-1 as a target for passive cancer ...
Web2 days ago · DKN-01 is a humanized monoclonal antibody that binds to and blocks the activity of the Dickkopf-1 ... DKK1 has an important role in mediating an immune ... WebJul 1, 2010 · Tumor tissues treated with anti-DKK1 displayed significant fibrotic changes and a decrease in viable cancer cells without apparent toxicity in mice, suggesting DKK1 as a serum biomarker for screening against a variety of cancers, and anti-dKK1 antibodies as potential theranostic tools for diagnosis and treatment of cancer. Dickkopf-1 (DKK1) is … WebDickkopf-1 (DKK1) is a known inhibitor of the Wnt signaling pathway, which plays an important role in a variety of cellular processes, including proliferation, differentiation, … c sharp table