Designing materials to direct stem-cell fate
WebSep 26, 2011 · MP Lutolf, PM Gilbert, HM Blau, Designing materials to direct stem-cell fate. Nature 462, 433–441 (2009). Crossref. PubMed. Google Scholar. 14. T Lecuit, PF Lenne, Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol 8, 633–644 (2007). WebTherefore, stem cells can be active components for materials nanoarchitectonics with delicate regulations of interactive information exchanges between materials and cells. Transmission of signals and information from material surface to living cells can induce complicated events of signal transductions and material conversions within the cells ...
Designing materials to direct stem-cell fate
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WebNov 1, 2009 · Designing 3D materials to control stem-cell fate in vitro. Whereas 2D approaches allow well-controlled analysis of the impact on stem cells of individual …
WebNov 30, 2015 · The extracellular matrix, a microenvironment of proteins and polymers that surrounds and connects cells, impacts a range of cellular behaviors including differentiation. For about a decade, researchers have been able to direct the fate of stem cells by tuning the mechanical stiffness of synthetic microenvironments such as hydrogels. Stem cells ... WebApr 16, 2024 · Studies of stem cell behavior on soft biomaterials have typically employed 2D platforms of synthetic polymers coated with monomeric protein ligands ().Such studies (2–4) have demonstrated that modulating the stiffness of porous gels can direct stem cell fate.However, experimental outcomes on amorphous biomaterial substrates vary widely.
WebNov 27, 2012 · It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, … WebNov 1, 2009 · Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial microenvironments in...
WebJan 12, 2010 · Controlling stem cell fate with material design Advances in our understanding of stem cell interactions with their environment are leading to the …
WebApr 9, 2024 · Stem cell therapy has broad application prospects in the repair of brain injury. One of the major challenges is exogenous NSCs differentiating into neurons. More recently, a variety of engineered fibrous scaffolds have been beneficial to the fate regulation of stem cells, thus promoting neural repair. philit vigil csu pueblo football twitterWebThe materials pipeline for biomaterials and tissue engineering applications is under continuous development. Specifically, there is great interest in the use of designed materials in the stem cell arena as materials can be … try hairmaxWebApr 14, 2024 · This work therefore provides new insights into the fundamental understanding of cell-material interactions, and will have a profound impact on further designing materials to direct stem cell fate ... phil ito bellevueWebDec 3, 2009 · Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful … tryhairfree.com reviewsWebIt is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, conventional cell … try haircuts on your photoWebFeb 5, 2024 · Many studies aim to identify reliable stem cell–materials grafts for cardiac repair. However, due to a lack of mechanistic understanding of cardiac regeneration, ... Lutolf MP, Gilbert PM, Blau HM (2009) Designing materials to direct stem-cell fate. Nature 462(7272):433–441. phil ivany. obituaryWebNov 1, 2013 · However, in vivo cell fate is likely influenced by a combination of geometry, mechanics and ECM composition [21], [22]. Thus we reasoned that combining these cues would prove useful in designing materials that more closely emulate the in vivo microenvironment and “fine-tune” a desired differentiation outcome. philit youtube